The Obstetric Care for Women with Opioid Use Disorder patient safety bundle underwent revision in November 2020. In the revision process, subject matter experts expanded the scope of this bundle to include substance use disorder more broadly and incorporated a 5th R of Respectful Care to ensure whole person, patient-centered, and trauma-informed care for every patient, in every clinical encounter. The Care for Pregnant and Postpartum People with Substance Use Disorder patient safety bundle was released in October 2021. For state, jurisdiction, and hospital-based teams interested in implementing a patient safety bundle related to substance use disorders, please utilize the Care for Pregnant and Postpartum People with Substance Use Disorder patient safety bundle.